As I continue my blogging series on deploying NSX-T 2.4 in your environment, my next topic will be Domains. This will be a quick blog as there is not a lot about setting up Domains. Domains will pop up a lot when configuring NSX-T. They are great for logically grouping a collection of workloads and objects which serve a common business goal. Creating domains makes it easier to manage objects in your environment.
I always select YES
It is really easy and simple to create a Domain and group different workloads. Sorting by groups or VMs make grouping objects simple.